Process Analytics in Biotechnological and Pharmaceutical Industries

Biopharmaceutical manufacturing is generally characterized by the use of advanced technologies, harnessing of new scientific advances, and driven by a highly complex research and development enterprise.

For decades, Knick has been advising and supporting companies worldwide on process analytics. Key competencies are the process-safe measurement of pH, ORP, conductivity and oxygen. In addition to sensors, Knick also offers innovative process analyzers, high-quality holders and fittings as well as unique cleaning and calibration systems.

Advanced technologies driven by highly complex research and development

The development of a novel active pharmaceutical ingredient typically requires large investments in time and capital to translate scientific discovery into new medicine and to build specialized manufacturing facilities and equipment, starting with the need to produce the initial supplies of an investigational compound for use in clinical trials prior to scale up to full-scale production upon FDA approval.

Nowadays it is nearly impossible to fight rare or complex diseases without therapies developed by the biopharma industry. Animal, or insect cells, bacteria, and yeast are genetically modified to produce target molecules like recombinant proteins, vaccines, and many more. Their manufacturing is a complex process due to the heterogeneity of the living organisms. Heterogeneity in the upstream process (USP) transfers to the subsequent product purification steps in downstream processes (DSP), too.

Automation throughout the upstream, downstream, and auxiliary processes helps to reduce the risks of human errors, improves operational efficiency, and thus increases the safety and quality of the final product.

Why Knick ?
As a specialist for measurement and control technology, Knick offers a high level of expertise and application knowledge in the field of liquid analysis in complex applications. The in-house vertical range of manufacturing ensures product quality and flexibility with regard to customer-specific requirements.
Customer proximity and reliability characterize the company just as much as its innovative products and technologies, which are used today globally by well-known manufacturers in the chemical and pharmaceutical sectors.

Biopharmaceutical Pathway: Solutions for every process step

Every process step of the biopharmaceutical pathway is important and requires specific measurement technology to control the critical process parameters for maximized yield, and reduced process deviations.

Knick offers complete measurement loops from sensors to fully automatic sensor maintenance systems. Automated processes help to maximize standardization, avoid transcription errors, and increase compliance.

With the Knick cCare Pharma system major goals of FDA’s PAT initiative are addressed:

Standardization of calibration and cleaning processes for less variations, and deviations
No more transcription errors leading to lessbatches lost
Audit trail ensures compliance with the regulations.

BioPharma Industry Brochure

Overview of specific applications and product solutions in various fields of BioPharma.

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Protos II 4400 S Modular Multiparameter-Transmitter | Wide Sensor Selection | Hygienic Surface | 4-Wire | Broad-Range Power Supply

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4400 S

SE547N pH Sensor | Memosens | 120 mm | CIP/SIP capable and autoclavable

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SE547N/1-NMSN-A2

SE554 pH/ORP Sensor | Memosens | 120 mm | Ex | For very high ionic strength media

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SE565 ORP Sensor | Memosens | 120 mm | Ex | For hygienic processes and sterile applications

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SE565X/1-NMSN

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SE571X/1-NMSN-LABS

SE620 2-Electrode Conductivity Sensor | VP | Pharma compliant hygienic design

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SE740 Optical Oxygen Sensor | M12 (8 pins) | 325 mm | For demanding hygienic environments

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Unical 9000 Electro-pneumatic controller | For automatic cleaning and calibration | Hygienic Surface

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Uniclean 900 Electro-pneumatic controller | For automatic cleaning | Hygienic Surface

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Process Analytics in Biotechnological and Pharmaceutical Industries

Advanced technologies driven by highly complex research and development

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Biopharmaceutical Pathway: Solutions for every process step

BioPharma Industry Brochure

Related Applications

Matching Products

Latest blog articles on Process Analytics

Uniclean 700 Series - Modular control system for automated sensor cleaning

Knick Austria - direct customer contact in Austria from 2024

Robust WA111 Retractable Fitting Made of Plastic for Highly Corrosive Operating Conditions

成功的聯合專案： 尼克公司開發了特殊的塞拉馬特 WA 155 可伸縮配件， 用於 SOPAT 的光學探頭

pH and conductivity measurement in vaccine production

Sturdy 2-Electrodes Conductivity Sensor SE625 with Coaxial Electrodes made of Titanium

Sensor Adapter with Lock Function Enables Safe and Thorough Cleaning

Up to six Sensors on one Transmitter Protos II 4400 via Modul MSU4400-180

ACHEMA 2022 - Knick at the world forum for the process industry

Combined pH- and ORP-Sensor SE555X/*-AMSN

MemoTrans MT201N: 适用于 Memosens 传感器的超紧凑型变送器

ProgaLog 4000 电脑端参数设置工具

采用 Profinet 技术的新型 Stratos Multi E461N 变送器

Memosens 2.0: Evolution of digital data transfer

SE655X 数字式和 SE656X 数字式 - 具有防爆认证的数字式电导率传感器

ILMAC 2021 in Basel - Trade Show Review by Knick Schweiz AG

Stratos Multi E401X - 用于易爆区域的多参数变送器

使用配备 EtherNet/IP 协议的 Stratos Multi E471 进行过程优化

新型数字式电导率传感器 SE656N

Transmitter for the process industry with PROFINET module

适合移动应用场景的高品质浸入式连接件

导电版模块化浸入式连接件

New multiparameter transmitter Stratos Multi

How to get the sensor into the process

Powerful compact analyzer boosts performance while reducing costs

High-Precision Conductivity Measurement at Extreme Temperature Differences

The Big Three of the Process Industry: HART, FF, Profibus

成功的聯合專案：尼克公司開發了特殊的塞拉馬特 WA 155 可伸縮配件，用於 SOPAT 的光學探頭