ANALYSE DES PROCESSUS

Surveillance des process de CIP/SIP

Monitoring CIP/SIP processes

In pharmaceutical, biological or process systems for food production, all process-wetted system components must be cleaned and sterilized at regular intervals. For this reason, during the cleaning in place (CIP) and sterilization in place (SIP) all relevant tubes and containers are rinsed and disinfected with the alkaline and acidic cleaning agents compatible with the process.

In SIP, process systems are also sterilized with superheated steam for 100% sterilization. The conductivity sensors for monitoring the cleaning process and cleaning agent concentration in the rinsing water must often resist extreme temperature fluctuations and aggressive cleaning agents.

Pharmacie et biotechnologie

Reliable conductivity measurement in cases of extreme temperature fluctuation

In CIP, coarse contamination is first removed by pre-flushing with water and cleaning agents and then flushed again to remove residual cleaning agent. Next, acidic cleaning solutions are used to remove lime and other mineral deposits. In the last steps, disinfectants are introduced and flushed out with ultrapure water in the final rinse.

In this cleaning procedure, after each step the conductivity of the rinsing water must be measured as a means of providing information on the remaining foreign substances in the water. If the measured values do not match the required specifications, the relevant step is repeated until the setpoints are present.

The SIP process follows. In it, the process system is not only disinfected but also sterilized by introducing ultrapure, non-pyrogenous steam (>120 °C). Depending on the specific processes, batch size and product variance, some systems must be cleaned and sterilized several times a day – in some cases, every hour.

The conductivity sensors used in SIP are exposed to extreme temperature fluctuations of ≥ 120 °C in a moist environment. Conductivity sensors must have robust and hygienic designs. They must also be equipped with industry-specific process connections and be made of FDA-compliant materials

The SE680 hygienic, inductive conductivity sensor for monitoring CIP rinsing circuits features an extremely broad measuring range of 0 … 2000 mS/cm at a resolution of 2 μS/cm. The sensor seamlessly monitors the entire cleaning process.

SE680 is extremely resilient – particularly in pharmaceutical sector applications – thanks to its lack of seals, joints and gaps and dirt-repellent surface made of FDA-approved Virgin PEEK.

During the final rinse with WFI (water for injection), the ultrapure water must have a non-temperature-compensated conductivity value of < 2.7 μS/cm, as a rule. Higher values indicate that there is residue in the water and another rinse is required.

Designed for the ultrapure water measuring range of 0.001…600 μS/cm, the SE605 H conductive conductivity sensor is used to monitor the final rinse. The SE605H has a hygienic design with two coaxially arranged electrodes made of electropolished stainless steel 1.4435 with a roughness depth of < 0.4 μm or < 0.8 μm. All of the materials used are FDA-compliant.

MemoRail analyzers are available for transferring measured values from the Memosens sensors to the control system. They transmit sensor and temperature values via a 4-20 mA output signal directly to the control system. A MemoRail variant with an interface for Modbus-based control systems is also available. A multi-parameter device in a compact, space-saving modular housing that comes in a 1- or 2-channel version, universal-use MemoRail is suitable with all Memosens sensors for measuring pH/ORP, oxygen and conductivity.

Return on Investment

Measuring loop cost-effectiveness is the focus of Memosens technology. Using Memosens significantly reduces investment costs for process analytics. Two 2-channel Memosens sensors can be connected to the MemoRail multi-parameter analyzer at the same time. The slim, compact modular housing simplifies installation in any system, even in tight installation spaces. The measurement signals are transmitted directly to the control system via -20 mA or Modbus.
Memosens also reduces and simplifies measuring loop maintenance, since the calibration data of Memosens sensors is saved directly in the sensor head. These robust, digital conductivity sensors monitor processes reliably and precisely.

Produits correspondants

SE680 Digital Toroidal Conductivity Sensor | For ARF 210/215 | FDA-approved PEEK | Measuring range 0 … 2000 mS/cm

Réf. produit :

SE680N-K8N4U00M

SE605H 2-Electrode Conductivity Sensor | Memosens | Ingold socket | Hygienic design

Réf. produit :

SE605H-NMSH

Industries et applications connexes

Pharmacie et biotechnologie

Solutions de mesure précises et durables pour répondre aux exigences strictes en amont et en aval du process

Entreprises de distribution: optimisation de l’analyse des liquides

In industrial processing plants such as oil refineries and pharmaceutical or chemical factories, many utility plants provide and extract the auxiliary media required by the main process.

Articles de blog sur ce sujet

févr. 2024

Process Analytics

Uniclean700, Launch

Uniclean 700 Series - Modular control system for automated sensor cleaning

With the Uniclean 700 series, Knick is introducing a modular control system, that can be installed very quickly and cost-effectively as a flexible entry-level solution for automated sensor cleaning.

déc. 2023

Company

|

Interface Technology

|

Process Analytics

Knick Austria - direct customer contact in Austria from 2024

Reorganization of sales in Austria and new contacts in the field of process analytics and interface technology

avr. 2023

Process Analytics

Launch, Fitting, WA111

Robust WA111 Retractable Fitting Made of Plastic for Highly Corrosive Operating Conditions

The plastic WA111 retractable fitting is a robust and cost-effective solution for corrosive processes and environments. It is equipped with a secure lock function and multiple nozzles for thorough sensor cleaning.

avr. 2023

Process Analytics

Launch, Fitting, WA155

Coopération réussie : Knick a développé un support rétractable spécial Ceramat WA 155 pour les sondes optiques de SOPAT.

Nettoyage automatique des sondes optiques dans les processus d'encrassement : Un projet commun de Knick et SOPAT pour une application client avec Ceramat.

avr. 2023

Process Analytics

Conductivity, Phamacy, pH

pH and conductivity measurement in vaccine production

Pharmaceutical contract manufacturer relies on Knick's transmitters for modular production plants for Covid-19 vaccines.

avr. 2023

Process Analytics

Conductivity, Sensor, SE625

Sturdy 2-Electrodes Conductivity Sensor SE625 with Coaxial Electrodes made of Titanium

The SE625 ensures reliable and accurate determination of the conductivity of ultrapure water in the semiconductor industry.

janv. 2023

Process Analytics

ARD75

Sensor Adapter with Lock Function Enables Safe and Thorough Cleaning

Sensor adapter with locking gate for safety and thorough cleaning of sensors in the immersion fitting ARD75 without the need

nov. 2022

Process Analytics

Protos II 4400, Module

Up to six Sensors on one Transmitter Protos II 4400 via Modul MSU4400-180

Users can now connect up to six Memosens sensors simultaneously.

août 2022

Process Analytics

Achema, Exhibition

ACHEMA 2022 - Knick at the world forum for the process industry

In August 2022, the international process industry met at the ACHEMA. Knick presented the cCare system and industrial applications in a new concept.

juin 2022

Process Analytics

pH, Sensor, SE555, ORP

Combined pH- and ORP-Sensor SE555X/*-AMSN

Combined pH and ORP measurement in one sensor SE555 saves place and equipment costs for demanding requirements in the chemical industry, the food sector and for hygienic applications.

avr. 2022

Process Analytics

MemoTrans

MemoTrans MT201N: Transmetteur ultracompact pour sondes Memosens

Le transmetteur ultracompact MemoTrans MT201 s'enfiche directement sur la sonde Memosens dans le support et communique via le protocole HART 4-20 mA.

févr. 2022

Process Analytics

Stratos Multi, Transmitter

Nouveau transmetteur Stratos Multi E461N avec Profinet

L'interface Profinet du nouveau transmetteur multiparamètres Stratos Multi E461N permet une communication continue des paramètres de process et une maintenance prédictive, du niveau du terrain jusqu'aux systèmes de contrôle des process usuels.

févr. 2022

Process Analytics

Protos II 4400, Stratos Multi, Software, ProgaLog

Programmation hors ligne confortable des transmetteurs sur PC: ProgaLog 4000

Avec ProgaLog 4000, vous pouvez facilement paramétrer hors ligne tous les transmetteurs à configuration modulaire Stratos Multi et Protos II 4400, enregistrer les réglages, les dupliquer pour d'autres transmetteurs et les documenter pour des audits.

janv. 2022

Process Analytics

Memosens

Memosens 2.0: Evolution of digital data transfer

As one of the two initiators of Memosens, Knick is constantly developing the technology.

nov. 2021

Process Analytics

Conductivity, Sensor, Ex, SE656, SE655

SE655X numérique et SE656X numérique – Sondes de conductivité numériques avec certification Ex

SE655X numérique et SE656X numérique avec rapport Memosens sont disponibles avec une certification Ex. Elles sont particulièrement adaptées à l’industrie chimique, du papier et de la cellulose ainsi qu'à la surveillance des eaux usées industrielles.

nov. 2021

Process Analytics

Exhibition, Switzerland, Ilmac

ILMAC 2021 in Basel - Trade Show Review by Knick Schweiz AG

Knick Schweiz AG exhibited at ILMAC in Basel and gives a brief review of what it's like to have finally met customers at the show again.

oct. 2021

Process Analytics

Stratos Multi, Transmitter, Ex

Stratos Multi E401X- Transmetteur multiparamètres pour zones Ex

Le nouveau Stratos Multi peut désormais être utilisé dans les zones Ex.

mai 2021

Process Analytics

Transmitters, Stratos Multi

Optimisation des process avec Stratos Multi E471 par EtherNet/IP

EtherNet/IP communication protocol allows the transmitter to be easily integrated into Industrial Ethernet networks as PCS.

mai 2021

Process Analytics

Launch, Conductivity, Sensor, SE656

Nouvelle sonde de conductivité numérique SE656N

New toroidal Digital Conductivity Sensor with a large measuring range and consisting of PFA for using in aggressive media

mars 2021

Process Analytics

Protos II 4400, Profinet

Transmetteur pour l'industrie de process avec le module PROFINET

Le standard Ethernet industriel PROFINET joue un rôle de plus en plus déterminant pour les techniques de process dans le contexte de l'industrie 4.0.

juil. 2020

Process Analytics

Launch, Fitting, ARD170

Canne d’immersion haute qualité pour applications mobiles

Avec l’ARD 170, Knick propose une canne d’immersion haute qualité pour mesures mobiles du pH, de la conductivité et de l’oxygène dissous. Les développeurs ont accordé une attention particulière à la simplicité et la flexibilité d’utilisation.

juil. 2020

Process Analytics

Fitting, ARD50, ARD75

Canne d'immersion modulaire en version électriquement conductrice

Avec ses cannes d'immersion ARD 50 EL et ARD 75 EL, Knick complète de deux versions électriquement conductrices (EL) son portefeuille de cannes d’analyse de liquides. Les modulaires permettent l’utilisation de sondes spécifiques aux applications.

avr. 2020

Process Analytics

Launch, Transmitters, Stratos Multi

New multiparameter transmitter Stratos Multi

Knick is launching the the next generation in its Stratos analyzer product line.

févr. 2018

Process Analytics

Fitting, Sensor

How to get the sensor into the process

Sensors as the direct interface to the process must be exactly matched to the chemistry of the measured medium and to the prevailing pressure and temperature conditions.

avr. 2017

Process Analytics

MemoRail Modbus

Powerful compact analyzer boosts performance while reducing costs

It has long been common practice when taking pH/ORP, conductivity, and oxygen measurements that a fixed analyzer be mounted near the sensor. The analyzer serves several purposes.