High-Precision Conductivity Measurement at Extreme Temperature Differences
Conductivity sensors used in hygienic applications have to withstand regular CIP (Cleaning in Place) and SIP (Sterilization in Place) processes as well as related strong temperature differences.
Therefore, EVER Pharma Jena uses the extremely robust conductivity sensors SE 605 H and SE 680 with Memosens technology from Knick Elektronische Messgeräte.
EVER Pharma Jena GmbH, which was founded in 1950 as VEB Jenapharm and had operated under the name Jenahexal until their acquisition by the Austrian pharmaceutical manufacturer EVER Pharma in 2011, has specialized in the production of aseptic and sterilized preparations in pharmaceutical phials, vials and pre-filled syringes. Today, the annual production capacities of the company amount to 130 million units. The product range includes neurological products, analgesics and hormones mainly for clinic supplies. The EVER Pharma Jena specializes on crystal suspensions as well as on hormone prepa-rations which are produced in strictly separate plants due to the risk of contamination.
Efficient CIP/SIP plant
Because of their wide range of products including different active substances, EVER Pharma Jena decided for a process design where the preparation tanks in the production aren’t connected with the filling via a static pipe system. Instead, the plant sections are decoupled through the use of mobile sterile filtrate tanks. “This allows us to have a significantly more flexible production at a higher product variant”, Martin Reuther, Project Manager at EVER Pharma Jena, says.
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One of the mobile sterile filtrate tanks that EVER Pharma Jena uses to filter out solid content from active substances. The tanks are cleaned and sterilized every hour.
Point of measurement of the SE 605 H. In the lower left corner of the picture you see the Memosens sensor connection.